Refining fine-mapping: Effect sizes and regional heritability.

ABSTRACT: Recent statistical approaches have shown that the set of all available genetic variants explains considerably more phenotypic variance of complex traits and diseases than the individual variants that are robustly associated with these phenotypes. However, rapidly increasing sample sizes constantly improve detection and prioritization of individual variants driving the associations between genomic regions and phenotypes. Therefore, it is useful to routinely estimate how much phenotypic variance the detected variants explain for each region by taking into account the correlation structure of variants and the uncertainty in their causal status. Here we extend the FINEMAP software to estimate the effect sizes and regional heritability under the probabilistic model that assumes a handful of cau

SUBMITTER: Benner C 

PROVIDER: S-EPMC11753704 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature