Multi-study fMRI outlooks on subcortical BOLD responses in the stop-signal paradigm.

ABSTRACT: This study investigates the functional network underlying response inhibition in the human brain, particularly the role of the basal ganglia in successful action cancellation. Functional magnetic resonance imaging (fMRI) approaches have frequently used the stop-signal task to examine this network. We merge five such datasets, using a novel aggregatory method allowing the unification of raw fMRI data across sites. This meta-analysis, along with other recent aggregatory fMRI studies, does not find evidence for the innervation of the hyperdirect or indirect cortico-basal-ganglia pathways in successful response inhibition. What we do find, is large subcortical activity profiles for failed stop trials. We discuss possible explanations for the mismatch of findings between th

SUBMITTER: Isherwood S 

PROVIDER: S-EPMC11753779 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature