Macrophage Evolution during Progression of Hepatitis Virus B-Related Acute-on-Chronic Liver Failure.

ABSTRACT:

Introduction

Hepatitis B virus (HBV)-related liver diseases, including hepatitis, cirrhosis, and liver failure, seriously threaten human lives and health worldwide. Innate and adaptive immune cells are all thought to participate in HBV-related diseases. However, there is a lack of information on the comprehensive landscape of the immune microenvironment.

Methods

In this study, single-cell ribonucleic acid sequencing was performed on liver samples obtained from patients diagnosed with hepatitis, cirrhosis, and acute-on-chronic liver failure, which were caused by HBV. Trajectory analysis was performed to analyze the evolution of cell subsets, and branch expression analysis modeling was applied to visualize the changes in gene expression during evolution.

Results

Finally

SUBMITTER: Rao J 

PROVIDER: S-EPMC11753795 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature