Coagulation assay results at birth in preterm infants: A cohort study highlighting the relevance of local reference values for interpretation.

ABSTRACT:

Background and objectives

Routine coagulation screens at birth are still standard in some European neonatal intensive care units (NICUs), although interpretation of these results is complex in preterm infants. It is unclear to what extent local coagulation assay results agree with published reference ranges when using different analysers and reagents. We aimed to assess coagulation assay results on day 1 of life in very preterm infants admitted to the NICU.

Materials and methods

We included all preterm infants born below 32 weeks gestational age (GA) admitted to the Leiden University Medical Center between 2004 and 2020 in whom coagulation assays (prothrombin time [PT] and activated partial thromboplastin time [APTT]) were obtained during the first 24 h of life. Infants eith

SUBMITTER: Houben N 

PROVIDER: S-EPMC11753824 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature