Ion confinement and separation using asymmetric electrodynamic fields in structures for lossless ion manipulations.

ABSTRACT:

Rationale

TW-SLIM ion mobility separations have demonstrated exceptional resolution by leveraging long paths with minimal loss. All previously reported experiments have used electrode surfaces which are mirrored to generate symmetrically opposing electric fields for ion confinement. However, work with other planar ion optics indicates this may be unnecessary. This study explores conditions under which separations may be obtained using a SLIM with asymmetric electric fields.

Methods

The asymmetric field configuration was defined by applying a uniform DC potential to all electrodes of the top PCB of a standard TW-SLIM board pair, with no electrode placement modifications. This configuration was simulated in SIMION to assess transmission through the SLIM. A benchtop TW-SLIM ins

SUBMITTER: Greer C 

PROVIDER: S-EPMC11753825 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature