Gene Expression Signatures of Smoking and Acute Myocardial Infarction: A Blood Transcriptome Analysis.

ABSTRACT: Background: Tobacco smoke is known to contain numerous harmful chemicals, and epidemiological evidence has firmly established smoking as a potent risk factor for hypertension and myocardial infarction (MI). However, the precise mechanisms by which smoking contributes to cardiovascular disease are not fully understood. The aim of this study is to identify common molecular signatures in blood that link smoking to acute MI (AMI). Methods: We extracted transcriptome data from seven blood microarray datasets in the Gene Expression Omnibus (GEO) database, encompassing a total of 403 patients. Employing both individual dataset analysis and a combined meta-analysis approach, we conducted a thorough examination of blood transcriptome profiles associated with AMI and smoking, uncoverin

SUBMITTER: Liu FF 

PROVIDER: S-EPMC11753852 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature