The environmental neuroactive chemicals list of prioritized substances for human biomonitoring and neurotoxicity testing: A database and high-throughput toxicokinetics approach.

ABSTRACT: There is a diversity of chemicals to which humans are potentially exposed. Few of these chemicals have linked human biomonitoring data, and most have very limited neurotoxicity testing. Of particular concern are environmental exposures impacting children, who constitute a population of heightened susceptibility due to rapid neural growth and plasticity, yet lack biomonitoring data compared to other age/population subgroups. This study set out to develop a prioritized list of neuroactive substances, titled the Environmental NeuRoactIve CHemicals (ENRICH) list, to be used as a defined screening library in the evaluation of human biological samples, with emphasis on early childhood-relevant environmental exposures. In silico database mining approaches were used to prioritize chemicals based u

SUBMITTER: Rager JE 

PROVIDER: S-EPMC11753932 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature