Prenatal and postnatal exposure to organophosphate esters and replacement flame retardant mixtures and childhood respiratory outcomes.

ABSTRACT:

Background

Early life exposure to single organophosphate esters (OPEs) and replacement brominated flame retardants (RBFRs) has been associated with adverse childhood respiratory outcomes, but the effects of OPE and RBFR mixtures are unknown.

Methods

377 pregnant women were recruited to the Health Outcomes and Measures of Environment (HOME) Study from 2003 to 2006 in Cincinnati, Ohio and later delivered singleton infants. We measured house dust OPEs and RBFRs prenatally at 20 weeks of gestation and postnatally at child age of 12 months and urinary OPEs prenatally at 16 and 26 weeks of gestation and at delivery and postnatally at child ages of 12 and 24 months. We performed Quantile G-computation (QG-computation) and Bayesian Kernel Machine Regression (BKMR) to assess the asso

SUBMITTER: Mendy A 

PROVIDER: S-EPMC11753936 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature