Towards the clinical translation of a silver sulfide nanoparticle contrast agent: large scale production with a highly parallelized microfluidic chip.

ABSTRACT:

Purpose

Ultrasmall silver sulfide nanoparticles (Ag₂S-NP) have been identified as promising contrast agents for a number of modalities and in particular for dual-energy mammography. These Ag₂S-NP have demonstrated marked advantages over clinically available agents with the ability to generate higher contrast with high biocompatibility. However, current synthesis methods for inorganic nanoparticles are low-throughput and highly time-intensive, limiting the possibility of large animal studies or eventual clinical use of this potential imaging agent.

Methods

We herein report the use of a scalable silicon microfluidic system (SSMS) for the large-scale synthesis of Ag₂S-NP. Ag₂S-NP produced using this system were compared to bulk synthe

SUBMITTER: Mossburg KJ 

PROVIDER: S-EPMC11753937 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature