Association between triglyceride-glucose index and endometriosis: results from a cross-sectional study and Mendelian randomization study.

ABSTRACT:

Background

Triglyceride-glucose (TyG) index has been found to be associated with female reproductive disorders, but its relationship with the risk of endometriosis is unknown. Therefore, the aim of this study was to investigate this relationship.

Methods

We performed a two-sample mendelian randomization(MR) analysis to examine the causal effect of TyG index on endometriosis, and inverse variance weighting(IVW) was the main method of analysis. Then, we selected 1484 participants with endometriosis from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006. Weighted multivariable-adjusted logistic regression and smoothed curve analysis were used to evaluate the correlation between the TyG index and endometriosis.

Results

The results of MR analy

SUBMITTER: Xu T 

PROVIDER: S-EPMC11753958 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature