Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma.

ABSTRACT:

Background

PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored.

Methods

We analyzed PLK3 expression in glioma samples from multiple databases. Both overexpression and knockdown of Plk3 were performed to investigate tumor cell growth in glioma, and the transplanted glioma mouse model demonstrated the role of Plk3 on tumor progression. Immunohistochemistry was conducted to detect PLK3 expression and immune cell infiltration. The trans-well assay for PLK3 on the immune cells recruitment was also determined. Additionally, we further evaluated the correlation between PLK3 and PD-1/PD

SUBMITTER: Zhu T 

PROVIDER: S-EPMC11753997 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature