Immune response profiling of HERV-W envelope proteins in multiple sclerosis: potential biomarkers for disease progression.

ABSTRACT:

Introduction

The envelope proteins syncytin-1 and pHERV-W from the Human Endogenous Retroviral family 'W' (HERV-W) have been identified as potential risk factors in multiple sclerosis (MS). This study aims to evaluate both humoral and cell-mediated immune response to antigenic peptides derived from these proteins across different clinical forms and inflammatory phases of MS.

Methods

Indirect enzyme-linked immunosorbent assay (ELISA) was employed to measure immunoglobulin G (IgG) responses to syncytin-1_{env 486-500} and pHERV-W_{env 486-504} peptides in MS patients. Discriminant analysis was used to assess whether clinical course prediction could be enhanced by integrating clinical variables with humoral response data against other MS-associated viral factors

SUBMITTER: Ruberto S 

PROVIDER: S-EPMC11754046 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature