Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents.

ABSTRACT:

Background

Lipid species are emerging as biomarkers for cardiometabolic risk in both adults and children. The genetic regulation of lipid species and their impact on cardiometabolic risk during early life remain unexplored.

Methods

Using mass spectrometry-based lipidomics, we measured 227 plasma lipid species in 1149 children and adolescents (44.8% boys) with a median age of 11.2 years. We performed genome-wide association analyses to identify genetic variants influencing lipid species. Colocalisation and Mendelian randomisation (MR) analyses were performed to infer causality between lipid species and cardiometabolic outcomes.

Findings

We identified 37 genome-wide significant loci for 52 lipid species, nine of which are previously unreported. Colocalisation analyses r

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11754075 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature