Photochemical permutation of thiazoles, isothiazoles and other azoles.

ABSTRACT: Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery^1,2. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study^3,4. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure of thiazoles and isothiazoles in a selective and predictable manner. On photoexcitation, these derivatives populate their π,π* singlet excited states that undergo a series of structural rearrangements, leading to an overall permutation of the cyclic system and its substituents. This m

SUBMITTER: Roure B 

PROVIDER: S-EPMC11754090 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature