Progressive plasticity during colorectal cancer metastasis.

ABSTRACT: As cancers progress, they become increasingly aggressive-metastatic tumours are less responsive to first-line therapies than primary tumours, they acquire resistance to successive therapies and eventually cause death^1,2. Mutations are largely conserved between primary and metastatic tumours from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression and therapy resistance^3-5. However, we lack an understanding of metastatic cell states and the mechanisms by which they transition. Here, in a cohort of biospecimen trios from same-patient normal colon, primary and metastatic colorectal cancer, we show that, although primary tumours largely adopt LGR5⁺ intestinal stem-like states, metastases display progressiv

SUBMITTER: Moorman A 

PROVIDER: S-EPMC11754107 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature