Bidirectional histone monoaminylation dynamics regulate neural rhythmicity.

ABSTRACT: Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression^1-3. We previously demonstrated that serotonylation^4-10 and dopaminylation^9,11-13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states. Here we found that TG2 additionally functions as an eraser and exchanger of H3 monoaminylations, including H3Q5 histaminylation (H3Q5his), which displays diurnally rhythmic expression in brain and contributes to circadian gene expression and behaviour. We found that H3Q5his, in contrast to H3Q5ser, inhibits the binding of WDR5, a core member of histone H3 Lys4 (H3K4) methyltransfera

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC11754111 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature