Central control of dynamic gene circuits governs T cell rest and activation.

ABSTRACT: The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks^1-3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The need for context-dependent regulation is prominent in T cells, where distinct lineages must respond to diverse signals to mount effective immune responses and maintain homeostasis^4-8. Here we performed CRISPR screens in multiple primary human CD4⁺ T cell contexts to identify regulators that control expression of IL-2Rα, a canonical marker of T cell activation transiently expressed by pro-inflammatory effector T cells and constitutively expressed by anti-inflammatory regulatory T cell

SUBMITTER: Arce MM 

PROVIDER: S-EPMC11754113 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature