Micromeria barbata for targeting MRSA virulence: In silico and in vitro studies.

ABSTRACT: The present study reports the characterization of the phytochemical content and the antibacterial activity of ethanolic extracts from the leaves (LE) and stems (SE) of Micromeria barbata (M.barbata) against Methicillin resistant Staphylococcus aureus (MRSA). Important functional groups were determined by analyzing the FTIR spectra of LE and SE. The phytochemical profiles were analyzed by GC-MS, and these characterized the chemicals according to retention periods and peak regions. The binding affinities of discovered compounds with the MRSA SarA and CrtM proteins were evaluated using molecular docking approach. Assays for biofilm formation, MIC, MBC, and agar well diffusion were used to assess the antimicrobial activity. From the FTIR spectra, hydroxyl group alkanes, am

SUBMITTER: Rawas S 

PROVIDER: S-EPMC11754165 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature