ESAT-6 protein suppresses allograft rejection by inducing CD4⁺Foxp3⁺ regulatory T cells through IκBα/cRel pathway.

ABSTRACT:

Background

Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells. ESAT-6 may be a potential alternative immunosuppressant that could be utilized to suppress allograft rejection although it remains unknown whether ESAT-6 actually regulates alloimmunity.

Methods

In this study, murine skin or heart allotransplantation was performed to determine the effect

SUBMITTER: Huang X 

PROVIDER: S-EPMC11754228 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature