Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients.

ABSTRACT:

Objectives

To assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients.

Methods

A population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling approach. The final model underwent evaluation through bootstrap resampling and visual predictive checks. Additionally, a population pharmacokinetic and pharmacodynamic analysis was conducted employing Monte Carlo simulations to investigate the impact of commonly used dosing regimens (0.25 g every 6 h, 0.5 g every 6 h, 0.5 g every 8 h, 1 g every 6 h, 1 g every 8 h, and 1 g every 12 h) on the likelihood of achieving the target therapeutic outcomes.

Results

A total of 370 observations available from 142 patients were incorp

SUBMITTER: Wang J 

PROVIDER: S-EPMC11754279 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature