Breathtaking dreams: reduced REM phenotype in REM-related sleep apnea.

ABSTRACT:

Purpose

The expression of the respiratory events in OSA is influenced by different mechanisms. In particular, REM sleep can highly increase the occurrence of events in a subset of OSA patients, a condition dubbed REM-OSA (often defined as an AHI 2 times higher in REM than NREM sleep). However, a proper characterization of REM-OSA and its pathological sequelae is still inadequate, partly because of limitations in the current definitions.

Methods

We propose a new interpretation of the REM-OSA definition, extending it from a AHI-ratio to a two-dimensional space, considering both time and events ratios in REM over NREM separately. Within this space, we analyzed current definitions of REM-OSA in three large clinical dataset and identified the underlying sources of heterogeneity.<

SUBMITTER: Cerina L 

PROVIDER: S-EPMC11754315 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature