Evaluation of a targeted anti-α_vβ₃ integrin near-infrared fluorescent dye for fluorescence-guided resection of naturally occurring soft tissue sarcomas in dogs.

ABSTRACT:

Purpose

Complete resection is a key prognostic factor for survival in patients with soft tissue sarcoma (STS), in humas and companion animals alike. Fluorescence-guided surgery could improve resection accuracy. As dogs are frequently affected by STS, they serve as a model to test an anti-α_vβ₃ integrin targeting near-infrared fluorescent (NIRF) dye (Angiostamp^TM800) for fluorescence-guided surgery in STS to evaluate its safety and feasibility in dogs, and if it translates into a clinically relevant benefit compared to the standard of care with regards to completeness of surgery and local recurrence. Furthermore, we aimed to correlate target expression and NIRF-signal intensity.

Methods

Twenty dogs with STS were randomly allocated to either rec

SUBMITTER: Beer P 

PROVIDER: S-EPMC11754361 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature