Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC.

ABSTRACT:

Introduction

Small cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, contributing to its aggressive progression and therapy resistance. Autophagy, a conserved cellular process, is implicated in many cancers, but its role in SCLC remains unclear.

Methods

Using a genetically engineered mouse model (Rb1^fl/fl ; Trp53^fl/fl ; GFP-LC3-RFP-LC3△G), we tracked autophagic flux in vivo to investigate its effects on SCLC biology. Additional in vitro experiments were conducted to modulate autophagic flux in NE and non-NE SCLC cell lines.

Results

Tumor subpopulations with high autophagic flux displayed increased proliferation, enhanced metastatic potential, and neuroendocrine (NE) characteristics.

SUBMITTER: Hao Y 

PROVIDER: S-EPMC11754400 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature