Thermal variation influences the transcriptome of the major malaria vector Anopheles stephensi.

ABSTRACT: The distribution and abundance of ectothermic mosquitoes are strongly affected by temperature, but mechanisms remain unexplored. We describe the effect of temperature on the transcriptome of Anopheles stephensi, an invasive vector of human malaria. Adult females were maintained across a range of mean temperatures (20 °C, 24 °C and 28 °C), with daily fluctuations of +5 °C and -4 °C at each mean temperature. Transcriptomes were described up to 19 days post-blood meal. Of the >3100 differentially expressed genes, we observed shared temporal expression profiles across all temperatures, suggesting their indispensability to mosquito life history. Tolerance to 20 and 28 ( + 5°C/-4°C) was associated with larger and more diverse transcriptomes compared to 24 ( + 5 °C/-4 °C). Finally, we identified

SUBMITTER: Pathak AK 

PROVIDER: S-EPMC11754467 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature