Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse.

ABSTRACT: Acute liver failure is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). The antidote, N-acetylcysteine (NAC), has limited efficacy when liver injury is established. If acute liver damage is severe, liver failure can rapidly develop with associated high mortality rates. We have previously demonstrated that alternatively, activated macrophages are a potential therapeutic option to reverse acute liver injury in pre-clinical models. In this paper, we present data using cryopreserved human alternatively activated macrophages (hAAMs)-which represent a potential, rapidly available treatment suitable for use in the acute setting. In a mouse model of APAP-induced injury, peripherally injected cryopreserved hAAMs reduced liver necr

SUBMITTER: Candela ME 

PROVIDER: S-EPMC11754469 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature