Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.

ABSTRACT:

Background

Many studies reported the influence of infants' gut microbiota on atopic dermatitis (AD) postnatally, yet the role of maternal gut microbiota and plasma metabolites in infants' AD remains largely unexplored.

Methods

Sixty-three pregnant mother-infants were enrolled and followed after childbirth in Guangzhou, China. Demographic information, maternal stool and plasma samples, and records for infants' AD were collected. Maternal gut microbiota/metabolome and plasma metabolome were profiled using shotgun metagenomics and non-targeted metabolomics. Logistic regression and multi-omics analysis were used to explore characteristic maternal gut microbiota in the AD and health groups.

Results

The α-diversity of maternal gut microbiota in health group was significantl

SUBMITTER: Du B 

PROVIDER: S-EPMC11754505 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature