The use of methylene blue in adult patients with septic shock: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Methylene blue exerts its vasopressor properties by inhibiting nitric oxide-mediated vasodilation. Recent studies have advocated the use of methylene blue as a rescue therapy for patients with septic shock. The primary aim was to investigate the effect of methylene blue on the mean arterial pressure among adult patients with septic shock.

Methods

Databases of MEDLINE, EMBASE, and CENTRAL were searched from their inception date until October 2023. Randomized Clinical Trials (RCT) comparing methylene blue and placebo in adults with septic shock were included.

Results

Our systematic review included 5 studies (n = 257) for data analysis. As compared to the placebo, our pooled analysis showed that methylene blue significantly increased mean arterial pressure (MD

SUBMITTER: Ng KT 

PROVIDER: S-EPMC11754512 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature