Spinal cord injury induces transient activation of hepatic stellate cells in rat liver.

ABSTRACT: Spinal cord injury (SCI) causes abnormal liver function, the development of metabolic dysfunction-associated steatotic liver disease features and metabolic impairment in patients. Experimental models also demonstrate acute and chronic changes in the liver that may, in turn, affect SCI recovery. These changes have collectively been proposed to contribute to the development of a SCI-induced metabolic dysfunction-associated steatohepatitis (MASH). However, none of the existent studies have focused on hepatic stellate cells (HSCs), liver resident cells that are the primary drivers of collagen deposition and fibrosis following sustained liver damage. Here, we describe the transient activation of HSCs after a thoracic contusion in rats, considered a clinically relevant model of experimental SCI.

SUBMITTER: Fernandez-Canadas I 

PROVIDER: S-EPMC11754611 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature