Evolution of intrinsic disorder in the structural domains of viral and cellular proteomes.

ABSTRACT: Intrinsically disordered regions are flexible regions that complement the typical structured regions of proteins. Little is known however about their evolution. Here we leverage a comparative and evolutionary genomics approach to analyze intrinsic disorder in the structural domains of thousands of proteomes. Our analysis revealed that viral and cellular proteomes employ similar strategies to increase disorder but achieve different goals. Viral proteomes evolve disorder for economy of genomic material and multifunctionality. On the other hand, cellular proteomes evolve disorder to advance functionality with increasing genomic complexity. Remarkably, phylogenomic analysis of intrinsic disorder showed that ancient domains were ordered and that disorder evolved as a benefit acquired later in e

SUBMITTER: Mughal F 

PROVIDER: S-EPMC11754631 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature