Generative design-enabled exploration of wireframe DNA origami nanostructures.

ABSTRACT: Recent advances in computer-aided design tools have helped rapidly advance the development of wireframe DNA origami nanostructures. Specifically, automated tools now exist that can convert an input polyhedral mesh into a DNA origami nanostructure, greatly reducing the design difficulty for wireframe DNA origami nanostructures. However, one limitation of these automated tools is that they require a designer to fully conceptualize their intended nanostructure, which may be limited by their own preconceptions. Here, a generative design framework is introduced capable of generating many wireframe DNA origami nanostructures without the need for a predefined mesh. User-defined objectives that guide the generative process are input as either single- or multi-objective optimization problems. A gra

SUBMITTER: Vetturini AJ 

PROVIDER: S-EPMC11754647 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature