A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator.

ABSTRACT:

Background

Adiposity is an established risk factor for colorectal cancer (CRC). The pathways underlying this relationship, and specifically the role of circulating proteins, are unclear.

Methods

Utilizing two-sample univariable Mendelian randomization (UVMR), multivariable Mendelian randomization (MVMR), and colocalization, based on summary data from large sex-combined and sex-specific genetic studies, we estimated the univariable associations between: (i) body mass index (BMI) and waist-hip ratio (WHR) and overall and site-specific (colon, proximal colon, distal colon, and rectal) CRC risk, (ii) BMI and WHR and circulating proteins, and (iii) adiposity-associated circulating proteins and CRC risk. We used MVMR to investigate the potential mediating role of adiposity- and CR

SUBMITTER: Lee MA 

PROVIDER: S-EPMC11754674 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature