Integrative proteomic analysis reveals the potential diagnostic marker and drug target for the Type-2 diabetes mellitus.

ABSTRACT:

Objective

The escalating prevalence of Type-2 diabetes mellitus (T2DM) poses a significant global health challenge. Utilizing integrative proteomic analysis, this study aimed to identify a panel of potential protein markers for T2DM, enhancing diagnostic accuracy and paving the way for personalized treatment strategies.

Methods

Proteome profiles from two independent cohorts were integrated: cohort 1 composed of 10 T2DM patients and 10 healthy controls (HC), and cohort 2 comprising 87 T2DM patients and 60 healthy controls. Differential expression analysis, functional enrichment analysis, receiver operating characteristic (ROC) analysis, and classification error matrix analysis were employed.

Results

Comparative proteomic analysis identified the differential expressed p

SUBMITTER: Jia Z 

PROVIDER: S-EPMC11754769 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature