The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes.

ABSTRACT: Brain anatomy plays a key role in complex behaviors and mental disorders that are sexually divergent. While our understanding of the sex differences in the brain anatomy remains relatively limited, particularly of the underlying genetic and molecular mechanisms that contribute to these differences. We performed the largest study of sex differences in brain volumes (N = 33,208) by examining sex differences both in the raw brain volumes and after controlling the whole brain volumes. Genetic correlation analysis revealed sex differences only in the left amygdala. We compared transcriptome differences between males and females using data from GTEx and characterized cell-type compositions using GTEx bulk amygdala RNA-seq data and LIBD amygdala single-cell reference profiles. We also constructed

SUBMITTER: Gui Y 

PROVIDER: S-EPMC11754786 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature