Ex vivo detection of recreational consumed nitrous oxide in exhaled breath.

ABSTRACT: The increasing use of recreational nitrous oxide ([Formula: see text]O) in the Netherlands and its link to traffic accidents highlights the need for reliable detection methods for law enforcement. This study focused on ex vivo detection of [Formula: see text]O in exhaled breath and examining its persistence in the human body. Firstly, a low-cost portable infrared based detector was selected and validated to detect [Formula: see text]O in air. Then, the influence of interferents and conditions potentially influencing the analysis were evaluated including relative humidity, ethanol, acetaldehyde and [Formula: see text]. Subsequently, [Formula: see text]O breathing dynamics were evaluated in vitro and ex vivo. Initially, a lung simulator was used to model respiratory mechanics and [Formula: s

SUBMITTER: Jimenez DD 

PROVIDER: S-EPMC11754840 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature