Mgl2⁺ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice.

ABSTRACT: Fungal spores are abundant in the environment and a major cause of asthma. Originally characterised as a type 2 inflammatory disease, allergic airway inflammation that underpins asthma can also involve type 17 inflammation, which can exacerbate disease causing failure of treatments tailored to inhibit type 2 factors. However, the mechanisms that determine the host response to fungi, which can trigger both type 2 and type 17 inflammation in allergic airway disease, remain unclear. Here we find that CD11c⁺ DCs and CD4⁺ T cells are essential for development of both type 2 and type 17 airway inflammation in mice repeatedly exposed to inhaled spores. Single cell RNA-sequencing with further multi-parameter cytometry shows that allergic inflammation dramatically alters the p

SUBMITTER: Cook PC 

PROVIDER: S-EPMC11754877 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature