Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles.

ABSTRACT: Polymeric nanoparticles (NPs) are promising tools used for immunomodulation and drug delivery in various disease contexts. The interaction between NP surfaces and plasma-resident biomolecules results in the formation of a biomolecular corona, which varies patient-to-patient and as a function of disease state. This study investigates how the progression of acute systemic inflammatory disease influences NP corona compositions and the corresponding effects on innate immune cell interactions, phenotypes, and cytokine responses. NP coronas alter cell associations in a disease-dependent manner, induce differential co-stimulatory and co-inhibitory molecule expression, and influence cytokine release. Integrated multi-omics analysis of proteomics, lipidomics, metabolomics, and cytokine datasets hig

SUBMITTER: Shaw JR 

PROVIDER: S-EPMC11754911 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature