Injectable thermosensitive antibiotic-laden chitosan hydrogel for regenerative endodontics.

ABSTRACT: Injectable biomaterials, such as thermosensitive chitosan (CH)-based hydrogels, present a highly translational potential in dentistry due to their minimally invasive application, adaptability to irregular defects/shapes, and ability to carry therapeutic drugs. This work explores the incorporation of azithromycin (AZI) into thermosensitive CH hydrogels for use as an intracanal medication in regenerative endodontic procedures (REPs). The morphological and chemical characteristics of the hydrogel were assessed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR). The thermosensitivity, gelation kinetics, compressive strength, cytocompatibility, and antibacterial efficacy were evaluated according to well-established pro

SUBMITTER: Reis-Prado AHD 

PROVIDER: S-EPMC11754974 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature