Dynamic association of antimicrobial resistance in urinary isolates of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> between primary care and hospital settings in the Netherlands (2008-2020): a population-based study.

ABSTRACT:

Background

It is unclear whether changes in antimicrobial resistance (AMR) in primary care influence AMR in hospital settings. Therefore, we investigated the dynamic association of AMR between primary care and hospitals.

Methods

We studied resistance percentages of Escherichia coli and Klebsiella pneumoniae isolates to co-amoxiclav, ciprofloxacin, fosfomycin, nitrofurantoin and trimethoprim submitted by primary care, hospital outpatient and hospital inpatient settings to the Dutch National AMR surveillance network (ISIS-AR) from 2008 to 2020. For each bacterium-antibiotic combination, we first conducted multivariable logistic regressions to calculate AMR odds ratios (ORs) by month and healthcare setting, adjusted for patient-related factors and a time term. Sec

SUBMITTER: Martinez EP 

PROVIDER: S-EPMC11755011 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature