MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways.

ABSTRACT: Nanozymes with specific catalytic activity inhibit inflammation and promote wound healing efficiently and safely. In this work, multifunctional manganese-based nanozymes (MnGA) with antioxidant properties were successfully constructed via a simple coordination reaction in which manganese chloride was used as the manganese source and gallic acid (GA) was used as the ligand solution. MnGA possesses both catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities and a reactive nitrogen species (RNS) scavenging capacity, which enables it to efficiently inhibit the inflammatory response. Specifically, MnGA scavenges superoxide anions and produces H₂O₂ via SOD-like activity and then consumes H₂O₂ to convert it to nontoxic H₂

SUBMITTER: Guo X 

PROVIDER: S-EPMC11755023 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature