Patient-Reported Fatigue Associated with Joint Histopathology in Rheumatoid Arthritis.

ABSTRACT:

Objective

Fatigue is important for patients with rheumatoid arthritis (RA) but is poorly understood. We sought to study associations of fatigue with clinical features, disease activity, and synovial histology.

Methods

Patients meeting the American College of Rheumatology/EULAR 1987 and/or 2010 RA criteria were recruited before elective total joint replacement. Demographics, RA characteristics, tender and swollen joints, erythrocyte sedimentation rate (ESR) and C-reactive protein, and patient-reported fatigue, categorized as mild, moderate, or severe, were collected. Hematoxylin and eosin stains of sectioned synovium were systematically scored by a pathologist. Relationships between fatigue and studied variables were evaluated with Kendall's tau. A directed acyclic graph (DAG

SUBMITTER: Pearce-Fisher D 

PROVIDER: S-EPMC11755064 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature