Nanopore decoding with speed and versatility for data storage.

ABSTRACT:

Motivation

As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA. We need flexible and efficient designs that match nanopore's capabilities, but relatively few designs have been explored and many have significant inefficiency in read density, error rate, or compute time. To address these problems, we designed a new single-read per-strand decoder that achieves low byte error rates, offers high throughput, scales to long reads, and works well for both DNA and RNA molecules. We achieve these results through a novel soft decoding algorithm that can be ef

SUBMITTER: Volkel KD 

PROVIDER: S-EPMC11755093 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature