Cholinergic Denervation Patterns in Parkinson's Disease Associated With Cognitive Impairment Across Domains.

ABSTRACT: Cognitive impairment is considered to be one of the key features of Parkinson's disease (PD), ultimately resulting in PD-related dementia in approximately 80% of patients over the course of the disease. Several distinct cognitive syndromes of PD have been suggested, driven by different neurotransmitter deficiencies and thus requiring different treatment regimes. In this study, we aimed to identify characteristic brain covariance patterns that reveal how cholinergic denervation is related to PD and to cognitive impairment, focusing on four domains, including attention, executive functioning, memory, and visuospatial cognition. We applied scaled sub-profile model principal component analysis to reveal cholinergic-specific disease-related and cognition-related covariance patterns using [

SUBMITTER: d'Angremont E 

PROVIDER: S-EPMC11755113 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature