Synergistic Effects of Extra X Chromosome on Development of Systemic Lupus Erythematosus and Sjogren Disease in Klinefelter and Triple X Syndrome: A Retrospective Cohort Study.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) and Sjögren disease (SjD) are autoimmune diseases with significant female predominance. The prevalence of SLE is increased in Klinefelter syndrome (KS) compared with the general male population. Our study investigates the dose effects of extra X chromosomes on the development of SLE and SjD in KS and triple X syndrome compared with the general population.

Methods

This multicenter, retrospective cohort study used TriNetX, a global federated research database. Using International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes, patients with a diagnosis of SLE or SjD in the general population, as well as those with SLE and SjD in KS (karyotype 47,XXY) and triple X syndrome (karyotype 47,XXX) from

SUBMITTER: Palmer AK 

PROVIDER: S-EPMC11755114 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature