Synthesis, Characterization, and Antimicrobial Activity of Urea-Containing α/β Hybrid Peptides against <i>Pseudomonas aeruginosa</i> and Methicillin-Resistant <i>Staphylococcus aureus</i>.

ABSTRACT: The insertion of β-amino acids and replacement of the amide bond with a urea bond in antimicrobial peptide sequences are promising approaches to enhance the antibacterial activity and improve proteolytic stability. Herein, we describe the synthesis, characterization, and antibacterial activity of short αβ cationic hybrid peptides LA^U-Orn-β^3,3Ac₆c-PEA, DY-01; LA^U-Lys-β^3,3Ac₆c-PEA, DY-02; and LA^U-Arg-β^3,3Ac₆c-PEA, DY-03 in which a C12 lipid chain is conjugated at the N terminus of peptide through urea bonds. Further, we evaluated all the peptides against both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) and their multidrug resi

SUBMITTER: Firdous S 

PROVIDER: S-EPMC11755142 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature