Novel D-Ribofuranosyl Tetrazoles: Synthesis, Characterization, In Vitro Antimicrobial Activity, and Computational Studies.

ABSTRACT: The goal of this study was to synthesize and evaluate new antimicrobial compounds. We specifically focused on the development of 2,5-disubstituted tetrazole derivatives containing the O-methyl-2,3-O-isopropylidene-(D)-ribofuranoside groups through N-alkylation reactions. The synthesized compounds were characterized using ¹H and ¹³C nuclear magnetic resonance (NMR) spectroscopy. Their antibacterial activity was tested against Pseudomonas aeruginosa, Escherichia coli, Streptococcus fasciens, and Staphylococcus aureus. Density functional theory (DFT) was applied to examine the electronic properties, including the highest occupied molecular orbital (HOMO)-least unoccupied molecular orbital (LUMO) gap, hardness, softness, density of states (DOS)

SUBMITTER: Sghyar R 

PROVIDER: S-EPMC11755160 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature