Real-Time Monitoring of Electrode Surface Changes in Fast-Scan Cyclic Voltammetry Using Fourier Transform Electrochemical Impedance Spectroscopy.

ABSTRACT: Fast-scan cyclic voltammetry (FSCV) is a widely used electrochemical technique to measure the phasic response of neurotransmitters in the brain. It has the advantage of reducing tissue damage to the brain due to the use of carbon fiber microelectrodes as well as having a high temporal resolution (10 Hz) sufficient to monitor neurotransmitter release in vivo. During the FSCV experiment, the surface of the carbon fiber microelectrode is inevitably changed by the fouling effect. In terms of redox peak potential and sensitivity against neurotransmitters, a changed electrode surface results in a voltammogram that differs from the precalibration. However, when an electrode is implanted in the brain, the method for monitoring the electrode status change is limited. In this study, we propose emplo

SUBMITTER: Park C 

PROVIDER: S-EPMC11755184 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature