Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.

ABSTRACT:

Importance

Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.

Objective

To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.

Design, setting, and participants

This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]). Data from 15 research and memory clinic studies were pooled and harmonized. Participants included individuals for whom data on age, cognitive status, amyloid status, and presence of CM

SUBMITTER: Oomens JE 

PROVIDER: S-EPMC11755193 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature