SERS profiling of blood serum filtrate components from patients with type II diabetes using 100 kDa filtration devices.

ABSTRACT: Blood carries some of the most valuable biomarkers for disease screening as it interacts with various tissues and organs in the body. Human blood serum is a reservoir of high molecular weight fraction (HMWF) and low molecular weight fraction (LMWF) proteins. The LMWF proteins are considered disease marker proteins and are often suppressed by HMWF proteins during analysis. This issue is addressed by using a filtration device to isolate the filtrate portion from blood serum samples having biomarker proteins up to the size of the cutoff value of the filtration device. In this research, 100 kDa filter devices are employed to obtain the filtrate portions from blood serum samples of type II diabetes mellitus patients and healthy volunteers, followed by characterization using surface-enhanced Ram

SUBMITTER: Shoukat Z 

PROVIDER: S-EPMC11755331 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature