Association of Dose of Inhaled Corticosteroids and Frequency of Adverse Events.

ABSTRACT:

Background

Inhaled corticosteroids (ICS) are the cornerstone of asthma treatment and significantly improve morbidity and mortality. Adverse effects of oral corticosteroids are well documented, but less is known about ICS.

Methods

We conducted observational studies in adults with asthma using two different UK nationwide datasets: Clinical Practice Research Datalink (CPRD) Aurum and CPRD GOLD. The exposure was incident ICS; the outcomes were major adverse cardiac events (MACE), arrhythmia, pulmonary embolism (PE) and pneumonia over 12-months. Our main analyses used a cohort method with stabilized inverse probability treatment weighting to balance confounding between exposed and unexposed patients. Secondary analyses included nested case-control studies, and self-controlled cas

SUBMITTER: Bloom CI 

PROVIDER: S-EPMC11755354 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature