Sex-specific Genetic Determinants of Right Ventricular Structure and Function.

ABSTRACT:

Rationale

While sex differences in right heart phenotypes have been observed, the molecular drivers remain unknown.

Objectives

To provide biological insights into sex differences in the structure and function of the right ventricle (RV) using common genetic variation.

Methods

RV phenotypes were obtained from cardiac magnetic resonance imaging in 18,156 women and 16,171 men from the UK Biobank. Observational analyses and sex-stratified genome-wide association studies were performed. Candidate female-specific loci were evaluated against invasively measured cardiac performance in 479 female patients with idiopathic or heritable pulmonary arterial hypertension (PAH), recruited to the UK NIHR BioResource Rare Diseases study.

Measurements and main results

Sex was ass

SUBMITTER: Harbaum L 

PROVIDER: S-EPMC11755371 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature